Thermodynamic study of asparagine and glycyl-asparagine using computational methods
نویسندگان
چکیده
منابع مشابه
The conformational locking of asparagine.
One dominant structure has been identified analysing the rotational spectrum of asparagine in sharp contrast with the multiconformational behaviour for other amino acids with polar side chains. This locking of the conformational variety to a single conformer has been ascribed to an intramolecular hydrogen bonding network involving α-amine, α-carboxylic and amide groups.
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PERSPECTIVES AND SUMMARY .............................................................. 631 STRUCTURES OF ASPARAGINE-LINKED OLIGOSACCI-IARIDES .................... 632 ASSEMBLY AND TRANSFER OF THE LIPID-LINKED OLIGOSACCHARIDE ...... 635 Assembly ............................................................................................ 635 Transfer-Oligosaccharide Structural Requirements ........
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In the title compound, C(10)H(12)N(2)O(5)S, one of the sulfonyl O atoms is hydrogen bonded to the amido N atom of an adjacent mol-ecule. There is also a weak hydrogen-bonding inter-action between the other sulfonyl O atom and the secondary amino N atom. In addition, the amido O atom is also hydrogen bonded to a carboxyl O atom. These hydrogen-bonding inter-actions give rise to a layer structure...
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Poly(lactic-co-glycolic acid) (PLGA) is a strong candidate for being a drug carrier in drug delivery systems because of its biocompatibility and biodegradability. However, in degrading PLGA matrices, the encapsulated peptide and protein drugs can undergo various degradation reactions, including deamidation at asparagine (Asn) residues to give a succinimide species, which may affect their potenc...
متن کاملN-(p-Tolylsulfonyl)-l-asparagine
In the title compound, C(11)H(14)N(2)O(5)S, the amide O atom acts as a hydrogen-bond acceptor from a carboxyl-ate O atom and a secondary amino N atom. In addition, one of the sulfonyl O atoms and the carbonyl O atom of the carboxyl group also form hydrogen bonds with the primary amido N atom. These intermolecular hydrogen-bonding inter-actions give rise to a layer structure, with the layers par...
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ژورنال
عنوان ژورنال: Brazilian Archives of Biology and Technology
سال: 2015
ISSN: 1516-8913
DOI: 10.1590/s1516-8913201500424